Zolasta 4 mg Injection

Zolasta 4mg Injection – Zoledronic Acid IP 4 mg by Intas

Zolasta 4mg Injection from Intas Pharmaceuticals contains Zoledronic Acid IP 4 mg as a sterile lyophilised powder for intravenous infusion. Zoledronic acid is a bisphosphonate: it binds to bone mineral and switches off osteoclasts, the cells that break bone down. With that demolition arm suppressed, bone formation gains the upper hand, bone density rises and the calcium that runaway resorption dumps into the bloodstream falls back. Supplied as a Combipack – the single-dose vial with a 5 ml ampoule of Sterile Water for Injection IP included free. Schedule H drug, given only by a healthcare professional.

Key Features

• Zoledronic Acid IP 4 mg sterile lyophilised single-dose vial
• Combipack – 5 ml Sterile Water for Injection IP supplied free
• Potent bisphosphonate that suppresses osteoclast bone breakdown
• For intravenous infusion over at least 15 minutes
• Schedule H – from Intas Pharmaceuticals Ltd.

Composition

• Zoledronic Acid Monohydrate equivalent to Zoledronic Acid IP – 4 mg
• Mannitol IP – 220 mg  |  Sodium Citrate IP – 24 mg
• Diluent ampoule: Water for Injection IP – 5 ml

Refer to the pack label and package insert for the complete list of excipients.

Uses & Benefits

• Treatment of osteoporosis, including postmenopausal and steroid-induced
• Lowers dangerously high blood calcium (hypercalcaemia of malignancy)
• Used in bone metastases and multiple myeloma to reduce skeletal complications
• Increases bone mineral density and helps reduce fracture risk
• Treatment of Paget’s disease of bone
• Long-acting – infrequent dosing compared with daily oral bisphosphonates

Directions for Use

• Administered by a healthcare professional only – never self-inject
• Reconstitute with the 5 ml Sterile Water for Injection IP provided in the pack
• Dilute further and infuse intravenously over at least 15 minutes
• Drink plenty of water before the infusion – good hydration protects the kidneys
• Do not mix with calcium-containing infusion solutions such as Ringer’s lactate

Precautions

• Do not use if the reconstituted solution shows visible particulate matter
• Kidney injury is the main risk – especially if you are dehydrated or on other kidney-affecting drugs. Kidney function is checked before each dose
• Osteonecrosis of the jaw can occur – have any needed dental work done before starting, maintain good oral hygiene, and report jaw pain, swelling or a loose tooth
• Can cause low blood calcium – your doctor will usually prescribe calcium and vitamin D alongside
• Common side effects include a flu-like reaction after the first dose (fever, headache, muscle and joint pain), which usually settles within a few days
• Not recommended in pregnancy or breastfeeding. Report any unusual thigh or groin pain, which can signal an atypical femoral fracture

Storage

• Store the sealed container at a temperature not exceeding 30°C
• Use the reconstituted solution promptly; do not store part-used vials
• Keep the medicine out of reach of children

Disclaimer

Schedule H prescription drug – to be sold by retail only on the prescription of a Registered Medical Practitioner, and administered under medical supervision. This information is for general awareness only and is not a substitute for professional medical advice, diagnosis or treatment.