Valest-1 Tablet

Valest-1 Tablet – Micronised Estradiol Valerate 1 mg by Walter Bushnell

Valest-1 from Walter Bushnell is a film-coated tablet containing Estradiol Valerate USP 1 mg (Micronised), an oestrogen used in hormone replacement therapy for menopausal symptoms and oestrogen deficiency. Two words on the label are doing real work. Valerate means this is an ester, not plain estradiol: the valeric acid side chain makes the molecule more fat-soluble so it survives absorption better, and the body then cleaves it off to release estradiol itself – the same hormone the ovaries produce. Micronised is the other half of the same problem: estradiol barely dissolves in water, and grinding it to very fine particles multiplies the surface area available to dissolve, which is what makes a 1 mg oral dose work at all. Together they turn a hormone that is poorly absorbed by mouth into a reliable daily tablet. Strip of 28 tablets, manufactured by Martin and Harris Laboratories.

Key Features

• Estradiol Valerate USP 1 mg (Micronised), film-coated tablets
• Micronised particles for reliable absorption of a poorly soluble hormone
• Valerate ester – cleaved in the body to release estradiol itself
• Colour: Brilliant Blue. Marketed by Walter Bushnell, New Delhi
• Strip of 28 tablets – a four-week course

Composition

• Estradiol Valerate USP (Micronised) – 1 mg
• Colour: Brilliant Blue. Film-coated tablet. As printed on the pack

Uses & Benefits

• Relieves hot flushes, night sweats and the other vasomotor symptoms of menopause
• Helps with vaginal dryness, discomfort and urinary symptoms caused by falling oestrogen
• Used in oestrogen replacement after the ovaries stop working or are removed
• Prescribed to help prevent post-menopausal osteoporosis in selected women
• Also used as part of hormone regimens under specialist direction
• A 28-tablet pack matching a four-week treatment cycle

Directions for Use

• Swallow one tablet a day with water, at the same time each day, or exactly as your doctor directs
• It may be taken with or without food
• The 28-tablet pack is a four-week course – your doctor will tell you whether to take it continuously or in a cycle
• If you still have a uterus, take the progestogen your doctor has prescribed alongside it, exactly as directed
• If you miss a dose, take it as soon as you remember unless the next one is nearly due. Do not double up – a missed dose may cause breakthrough bleeding

Precautions

• If you still have a uterus, oestrogen must not be taken alone. Unopposed oestrogen thickens the womb lining and raises the risk of endometrial cancer – a progestogen is prescribed alongside it for this reason. Never drop the progestogen and continue this on its own
• HRT slightly raises the risk of breast cancer, blood clots in the leg or lung, stroke and gallbladder disease. The size of that risk depends on your age, how long since menopause and how long you take it – your doctor weighs it against the benefit at least once a year
• Not for use if you have or have had breast cancer, an oestrogen-dependent cancer, unexplained vaginal bleeding, active or previous blood clots, severe liver disease, or are pregnant
• Tell your doctor about migraine, high blood pressure, diabetes, gallstones, fibroids, endometriosis, epilepsy, asthma, lupus or a family history of breast cancer or clots
• Report any unexpected vaginal bleeding, a breast lump, calf pain or swelling, sudden breathlessness or chest pain, severe headache, or yellowing of the eyes immediately
• Breast tenderness, nausea, headache, bloating and mood change are common in the first weeks and usually settle. Keep up your breast screening and cervical screening appointments

Storage

• Store in a cool, dry and dark place, as printed on the pack
• Keep the tablets in the blister until you take them
• Keep out of reach of children

Disclaimer

Schedule H prescription drug – to be sold by retail on the prescription of a Registered Medical Practitioner only. Hormone replacement therapy carries risks that differ with age, time since menopause and personal history, and it must be started, reviewed and stopped under medical supervision. This information is for general awareness and is not a substitute for professional medical advice, diagnosis or treatment.