Syncapone 100 Tablet

Syncapone 100 Tablet – Levodopa 100 mg + Carbidopa 25 mg + Entacapone 200 mg by Sun Pharma

Syncapone 100 from Sun Pharma is a three-drug film-coated tablet: Levodopa IP 100 mg, Carbidopa (anhydrous) 25 mg and Entacapone IP 200 mg. Each blocks a different escape route for levodopa. Carbidopa stops the enzyme that converts levodopa to dopamine in the bloodstream; entacapone blocks COMT, a second enzyme that quietly disposes of levodopa by another pathway. With both blocked, more of each dose survives the journey to the brain and stays active longer – which is why this combination is used when doses have begun wearing off before the next is due. The pack specifies dosing by a neurologist only. Strip of 10 tablets. Schedule H prescription medicine.

Key Features

• Levodopa 100 mg + Carbidopa 25 mg + Entacapone 200 mg film-coated tablet
• Two enzyme blockers – carbidopa and entacapone close off both breakdown routes
• For end-of-dose wearing-off, when plain levodopa no longer lasts
• Extends the useful life of each levodopa dose
• Strip of 10 tablets from Sun Pharmaceutical Industries Ltd.

Composition

• Levodopa IP – 100 mg
• Carbidopa (anhydrous) – 25 mg
• Entacapone IP – 200 mg
• Per film-coated tablet

Composition as printed on the pack. Refer to the package insert for the complete list of excipients.

Uses & Benefits

• Reduces the tremor, stiffness and slowness of Parkinson’s disease
• Extends how long each levodopa dose keeps working
• Reduces end-of-dose wearing-off and off periods
• Three medicines in one tablet, simplifying a complex regimen
• Carbidopa cuts the nausea plain levodopa causes
• Improves the ability to walk, write, dress and manage daily tasks

Directions for Use

• Take exactly as prescribed – the dose and timing are worked out individually and adjusted over time
• Take it at the same times every day. With this medicine timing matters more than with almost any other; a late dose can mean symptoms return
• Avoid taking it with a high-protein meal – dietary protein competes with levodopa for absorption and can blunt the dose
• If nausea troubles you, a light non-protein snack with the dose can help. Ask your doctor first
• Never stop suddenly. Abrupt withdrawal can cause a dangerous reaction with fever and muscle rigidity

Precautions

• Do not stop this medicine abruptly – sudden withdrawal can trigger a severe reaction with high fever and muscle stiffness needing emergency care
• Dizziness on standing is common, particularly early on. Rise slowly from sitting or lying
• Sudden sleep attacks can occur without warning drowsiness – do not drive or operate machinery until you know how this affects you
• Involuntary writhing movements (dyskinesia) may develop after long use, and each dose may start wearing off early. Report both – the regimen can be adjusted
• Impulse control problems (gambling, compulsive shopping, eating or sexual urges) have been reported. Tell your doctor or family if behaviour changes
• Urine, sweat or saliva may darken. This is harmless
• Tell your doctor about glaucoma, heart disease, ulcers, kidney or liver disease, or a history of melanoma; do not take with MAO inhibitors
• Entacapone turns urine a harmless reddish-brown. Expect it, and do not be alarmed
• Diarrhoea can appear weeks into treatment – report it, as it sometimes needs the drug stopped

Storage

• Store at room temperature, protected from light and moisture
• Keep tablets in the original blister until use
• Keep out of reach of children

Disclaimer

Schedule H prescription drug – to be sold by retail on the prescription of a Neurologist only, as stated on the pack. This information is for general awareness and is not a substitute for professional medical advice, diagnosis or treatment.