Duotrol 2.5mg/500mg Tablet SR

Duotrol 2.5mg/500mg Tablet SR is a fixed-dose combination medicine belonging to the anti-diabetic class of drugs, used to manage type 2 diabetes mellitus in adults. It combines Glibenclamide, a sulfonylurea that stimulates the pancreas to release more insulin, with Metformin Hydrochloride in sustained-release form, which lowers glucose production in the liver, delays glucose absorption from the intestines, and increases the bodys sensitivity to insulin. Together, this combination helps control blood sugar levels more effectively than either medicine used alone.

• Glibenclamide – 2.5 mg
• Metformin Hydrochloride – 500 mg, in sustained release form

This medicine is prescribed when blood sugar is not adequately controlled by a single antidiabetic medicine or by diet and exercise alone. Duotrol 2.5mg/500mg Tablet SR should be taken with food, at the same time each day, exactly as directed by the physician, since the correct dose depends on individual blood sugar readings and may be adjusted from time to time. The tablet should be swallowed whole and not chewed, crushed or broken, as this would interfere with its sustained-release action.

It is important to continue taking this medicine regularly, even when feeling well or when blood sugar appears controlled, since stopping it without medical advice can allow blood sugar to rise again and increase the risk of long-term complications such as kidney damage, vision problems, nerve damage and poor wound healing. Alongside medication, a healthy diet, regular physical activity and weight management play a major role in controlling type 2 diabetes.

The most common effects reported with this medicine include nausea, vomiting, diarrhea, abdominal pain and headache, which usually settle down as the body adjusts. Because Glibenclamide increases insulin release, this medicine can cause hypoglycaemia (low blood sugar), especially if a meal is delayed or skipped, or if alcohol is consumed, so regular meals and awareness of symptoms like sweating, shakiness and dizziness are important. This medicine is not suitable for people with type 1 diabetes, diabetic ketoacidosis, or severe kidney or liver disease, and should be used cautiously in those with a history of heart disease. Doctors may periodically check liver function and kidney function during long-term use, and the medicine is usually paused before surgery or procedures involving contrast dye.

Duotrol 2.5mg/500mg Tablet SR is marketed by USV Private Limited and is available as a strip of 10 sustained-release tablets. Store in a cool, dry place away from direct sunlight and out of reach of children. As a prescription medicine, it should only be used under the supervision of a registered physician.