Esomeza-40 Tablet

Esomeza-40 Tablet – Esomeprazole Magnesium Gastro-Resistant Tablets IP 40 mg by Knoll

Esomeza-40 from Knoll Pharmaceuticals is Esomeprazole Magnesium Gastro-Resistant Tablets IP 40 mg. Esomeprazole is the cleanest illustration in the whole PPI class of what chemistry can buy you. Omeprazole is a racemic mixture – half S-isomer and half R-isomer, mirror images of the same molecule. The liver clears the R-isomer quickly through CYP2C19; the S-isomer is cleared more slowly and more predictably. Esomeprazole is simply that S-isomer isolated and sold on its own, and the practical consequence is a higher and steadier drug level from the same nominal dose, less variation between one patient and the next, and better healing rates in severe erosive oesophagitis in head-to-head trials. The gastro-resistant coating carries it past stomach acid intact, so the tablet has to be swallowed whole. Strip of 10 tablets.

Key Features

• Esomeprazole Magnesium Gastro-Resistant Tablets IP 40 mg
• Esomeprazole is the S-isomer of omeprazole – cleared more slowly and more predictably
• Higher, steadier acid suppression from the same nominal dose
• Gastro-resistant coating – swallow whole, never crush
• Strip of 10 tablets from Knoll Pharmaceuticals Ltd.

Composition

• Esomeprazole Magnesium IP – equivalent to Esomeprazole 40 mg
• Gastro-resistant (enteric-coated) tablets. As printed on the carton

Uses & Benefits

• Heals severe erosive oesophagitis and reflux oesophagitis
• Treats GERD, heartburn and acid regurgitation that need a strong PPI
• Heals gastric and duodenal ulcers and helps prevent recurrence
• Used with antibiotics to eradicate H. pylori
• Prevents NSAID-associated gastric ulcers in people at risk
• More consistent between patients than plain omeprazole

Directions for Use

• Take it 30 to 60 minutes before a meal, usually before breakfast, or exactly as your doctor directs
• Swallow it whole with water. Do not chew, crush or break it – the enteric coating is what gets the drug past stomach acid intact
• Take it at the same time each day, and finish the full course even if the symptoms settle early
• If you miss a dose, take it when you remember unless the next is nearly due. Never take two together
• Avoid or limit alcohol, smoking, and food that triggers your symptoms while you are being treated

Precautions

• Take it 30 to 60 minutes before food, not after. A proton pump inhibitor only shuts down pumps that are actively working, and they switch on when you eat – taken after a meal it does a fraction of the job
• These are not antacids and do not work in minutes. Full acid suppression builds over three to five days; keep an antacid for immediate relief if your doctor agrees
• Long-term use is not harmless. Months or years of treatment are linked to low magnesium, low vitamin B12, reduced calcium absorption and a higher risk of fractures, and to gut infections such as C. difficile. Use the lowest dose for the shortest time that controls symptoms
• Do not stop a long course abruptly – acid can rebound above where it started, and the symptoms can be mistaken for the original problem returning. Ask your doctor about tapering
• Tell your doctor about difficulty swallowing, vomiting blood, black stools, unintended weight loss or persistent vomiting. Acid suppression can mask a more serious problem
• Tell your doctor about liver disease, lupus, low magnesium, and every other medicine you take – especially clopidogrel, methotrexate, digoxin, antifungals, HIV medicines and warfarin

Storage

• Store below 30°C, protected from light and moisture
• Keep the tablets in the blister until use
• Keep out of reach of children

Disclaimer

Schedule H prescription drug – to be sold by retail on the prescription of a Registered Medical Practitioner only. Acid-suppressing medicines are meant for a defined course, not indefinite self-treatment. This information is for general awareness and is not a substitute for professional medical advice, diagnosis or treatment.