Trenaxa-SR 750 Tablet

Trenaxa-SR 750 Tablet – Tranexamic Acid 750 mg Sustained Release by Macleods

Trenaxa-SR 750 from Macleods is a sustained release film-coated tablet of Tranexamic Acid IP 750 mg, used mainly to reduce heavy menstrual bleeding and to control bleeding in a range of other settings. The way it works is worth understanding, because it is not a clotting factor and it does not make blood clot faster. When the body forms a clot it simultaneously starts dismantling it: plasminogen converts to plasmin, and plasmin dissolves the fibrin mesh holding the clot together. In heavy menstrual bleeding that dismantling process runs too fast in the uterine lining, so clots break down before they can seal the vessels. Tranexamic acid blocks the sites on plasminogen that let it bind to fibrin – the clot that has already formed simply lasts longer. It is non-hormonal, taken only on bleeding days, and does not affect the cycle. Strip of 10 SR tablets.

Key Features

• Tranexamic Acid IP 750 mg in a sustained release film-coated tablet
• Non-hormonal – no effect on the cycle, ovulation or fertility
• Taken only on the heavy days, not throughout the month
• Sustained release, so fewer tablets a day than plain 500 mg
• Strip of 10 tablets from Macleods Pharmaceuticals Ltd.

Composition

• Tranexamic Acid IP – 750 mg (in sustained release form)
• Sustained release film-coated tablet. Excipients q.s. As printed on the strip

Uses & Benefits

• Reduces the volume of blood lost in heavy menstrual periods
• Taken only on the heavy days, not every day of the month
• Non-hormonal – it does not affect the cycle, ovulation or fertility
• Also prescribed for nosebleeds, dental extraction bleeding and other bleeding problems
• Works within the first cycle, so the effect is easy to judge
• Fits alongside iron replacement where periods have caused anaemia

Directions for Use

• Swallow the tablet whole and do not chew it, as printed on the strip – chewing destroys the sustained release
• Take it exactly as your doctor directs, usually starting when the heavy bleeding begins and continuing for the days prescribed
• It can be taken with or without food; with food if it upsets your stomach
• Do not exceed the prescribed number of days in a cycle
• Keep well hydrated while taking it

Precautions

• Tell your doctor at once if you have ever had a blood clot in the leg or lung, a stroke or a heart attack. Tranexamic acid slows clot breakdown, so it is not given where a clot has occurred or is likely
• It should not be taken with combined hormonal contraceptives without specialist advice – both raise clotting risk
• Not for people with active intravascular clotting, colour vision defects, or bleeding from the kidney or urinary tract, where a clot could block the outflow
• The dose is reduced in kidney impairment. Tell your doctor about kidney disease, seizures, or a history of subarachnoid haemorrhage
• Nausea, vomiting and diarrhoea are the usual side effects and settle with food. Report any calf pain or swelling, chest pain, breathlessness, sudden severe headache or a change in vision immediately
• Heavy bleeding needs a diagnosis. This controls the symptom – fibroids, polyps, thyroid problems and clotting disorders still need investigating

Storage

• Store protected from moisture at a temperature not exceeding 30°C, as printed on the strip
• Keep the tablets in the blister until use
• Keep all medicines out of reach of children

Disclaimer

Schedule H prescription drug – to be sold by retail on the prescription of a Registered Medical Practitioner only. This information is for general awareness and is not a substitute for professional medical advice, diagnosis or treatment. Heavy or abnormal bleeding always needs a cause to be found; do not treat it with an antifibrinolytic on your own.