Hepcinat Tablet

Hepcinat Tablet – Sofosbuvir 400 mg by Natco

Hepcinat Tablet from Natco Pharma contains Sofosbuvir 400 mg, the nucleotide analogue that transformed hepatitis C from a hard-to-treat chronic infection into a curable one. It works by inhibiting NS5B polymerase, the enzyme the virus depends on to copy its own RNA; once that step is blocked, viral replication stops. Sofosbuvir is not used on its own – it is always combined with another direct-acting antiviral such as daclatasvir, velpatasvir or ledipasvir, and sometimes with ribavirin, depending on genotype and liver status. Strip of 28 tablets, four weeks of therapy.

Key Features

• Sofosbuvir 400 mg – NS5B polymerase inhibitor
• Backbone of nearly every modern hepatitis C regimen
• Always used in combination with another antiviral, never alone
• One tablet daily, with or without food
• Strip of 28 tablets from Natco Pharma Ltd.

Composition

• Sofosbuvir – 400 mg per tablet (NS5B polymerase inhibitor)

Refer to the pack label and package insert for the complete list of excipients.

Uses & Benefits

• Treatment of chronic hepatitis C virus (HCV) infection, in combination with other antivirals
• Steadily lowers the amount of virus in the blood over the course of treatment
• High cure rates when the full prescribed course is completed
• Can be used in compensated cirrhosis under specialist supervision
• Clearing the virus reduces the long-term risk of liver failure and liver cancer
• Simple one-tablet-a-day dosing alongside the partner medicine

Directions for Use

• Take exactly as prescribed – usually one tablet once daily with the partner antiviral
• Swallow the tablet whole with water; do not chew, crush or break it
• May be taken with or without food, but keep to the same time each day
• Complete the full course even when you feel well – stopping early risks relapse and resistance
• If you miss a dose, take it as soon as you remember unless the next is near; never double up

Precautions

• You must be tested for hepatitis B before starting. HBV can reactivate during HCV treatment and cause serious, sometimes fatal, liver injury
• Do not take with amiodarone – the combination can cause severe, potentially fatal slowing of the heart
• Never take sofosbuvir alone. Monotherapy does not cure hepatitis C and encourages resistance
• Tell your doctor about all other medicines, especially rifampicin, carbamazepine, phenytoin, St John’s Wort and certain HIV medicines, which can make treatment fail
• Common side effects include headache, tiredness, nausea and insomnia; anaemia is more likely if ribavirin is added
• Avoid alcohol; use with caution in severe kidney disease, and do not drive if you feel dizzy

Storage

• Store below 30°C in a dry place
• Keep in the original pack, protected from light and moisture
• Keep out of reach of children

Disclaimer

Prescription medicine – not to be sold by retail without the prescription of a Registered Medical Practitioner. This information is for general awareness only and is not a substitute for professional medical advice, diagnosis or treatment. Hepatitis C therapy must be started and monitored by a qualified hepatologist or physician.