Cilnep-Trio from Leeford Healthcare puts Telmisartan 40 mg, Cilnidipine 10 mg and Chlorthalidone 12.5 mg into one tablet. A three-drug tablet exists because high blood pressure that resists treatment usually resists it for more than one reason, and the three ingredients attack three separate ones: telmisartan blocks the hormone signal that constricts vessels, cilnidipine blocks the calcium channels that keep vessel muscle contracted, and chlorthalidone reduces the fluid volume the heart has to move. Chlorthalidone is the diuretic worth noting – it is longer-acting than hydrochlorothiazide and, in outcome trials, has performed better at preventing cardiovascular events. Cilnidipine adds the L/N-type channel action that spares patients the ankle swelling amlodipine causes. Strip of 10 tablets. Schedule H prescription medicine.

Key Features

• Telmisartan 40 mg + Cilnidipine 10 mg + Chlorthalidone 12.5 mg in one tablet
• Three mechanisms – hormone blockade, calcium channel blockade and fluid reduction
• Chlorthalidone – longer-acting than hydrochlorothiazide
• Cilnidipine – far less ankle swelling than amlodipine
• Strip of 10 tablets from Leeford Healthcare Ltd.

Composition

• Telmisartan – 40 mg
• Cilnidipine – 10 mg
• Chlorthalidone – 12.5 mg
• Per tablet, as printed on the pack

Composition as printed on the pack. Refer to the package insert for the complete list of excipients.

Uses & Benefits

• Brings blood pressure down when two medicines have not been enough
• Three complementary mechanisms in a single daily tablet
• Replaces three separate tablets, which helps long-term adherence
• Reduces the long-term risk of stroke, heart attack and heart failure
• Attacks pressure from vessel tone, calcium channels and fluid volume at once
• No dry cough, unlike ACE inhibitor combinations

Directions for Use

• Take one tablet once daily, exactly as prescribed, at the same time each day
• Take it in the morning – the diuretic increases urination, and an evening dose disturbs sleep
• Swallow the tablet whole with water; may be taken with or without food
• Keep taking it even when you feel well – high blood pressure usually has no symptoms
• Do not stop or change the dose on your own; pressure rebounds when treatment stops

Precautions

• Stop immediately and contact your doctor if you become pregnant. The pack warns that telmisartan can cause injury and even death to the developing baby when used in the second and third trimesters
• Seek emergency care for swelling of the face, lips, tongue or throat
• The diuretic can lower potassium and sodium and raise uric acid and blood sugar. Tell your doctor if you have gout or diabetes, and keep to the blood test schedule
• Dizziness on standing is common early on, and worse if you are dehydrated
• Tell your doctor about kidney disease, renal artery narrowing, liver disease, or if you take NSAIDs or lithium
• Do not combine with an ACE inhibitor or aliskiren unless a specialist directs it

Storage

• Store below 30°C, protected from light and moisture
• Keep tablets in the original blister until use
• Keep out of reach of children

Disclaimer

Schedule H prescription drug – not to be sold by retail without the prescription of a Registered Medical Practitioner. This information is for general awareness and is not a substitute for professional medical advice, diagnosis or treatment. Telmisartan must be stopped as soon as pregnancy is detected; blood pressure treatment must be reviewed regularly by your doctor.

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